Archives for February 2023

Top 80 Medical Device Conferences in 2023

30 min reading time

Medical Device Conferences 2023 is our most comprehensive list of medical device conferences, trade shows, events, and meetings for the medical device industry.
These are the conferences, trade shows, and events the world’s leading professionals attend to do business, learn, and build and solidify relationships.
We at the Medical Devices Group make every effort for the list to be the best and most complete.

If an event is missing, please add it for free:

    1. 11th Annual Acute Care of the Complex Hospitalized Patient for NPs And PAs
      February 15-18, 2023 • Scottsdale, AZ US

      As hospital care models continue to evolve; NPs and PAs are playing an increasingly vital role in the care delivery of hospitalized patients. This conference focuses on providing the most up-to-date, evidence-based guidelines and treatment pathways necessary to optimally care for hospitalized patients. The course covers topics in critical care, hospital general medicine, surgery, neurology, hematology, cardiology, psychology, pain management and other medical subspecialties and features multiple options for skills workshops to further tailor the educational needs of NPs and PAs.
    2. University of Chicago Oncology Conference for Adults and Pediatrics
      February 17-18, 2023 • Grand Hyatt Abu Dhabi Hotel and Residences Emirates Pearl

      On behalf of the Scientific and Organizing Committee, it is an honor and privilege to invite you to attend the “University of Chicago Oncology Conference for Adults and Pediatrics” being held hybrid on 17-18 February, at Grand Hyatt Hotel in Abu Dhabi, UAE. The conference is set to bring together the latest oncology research and knowledge during a comprehensive two-day Pediatrics & Adults program. The event will feature state of the art advances in oncology treatment delivered through an expert panel of University of Chicago Medicine faculty and regional experts from the Gulf Region.
    3. Clinical Hematology and Oncology 2023
      Februay 18-20, 2023 • Hyatt Regency La Jolla At Aventine

      The 2023 Clinical Hematology and Oncology Conference, presented by Scripps MD Anderson Cancer Center, is designed for hematologists, oncologists, surgeons, radiation oncologists, internists, and others desiring an update in these specialty areas. The primary objective of this course is to bring together clinicians and leading experts in diverse areas of hematology and oncology, affording them an intimate environment in which to discuss new clinical developments and significant advances.
    4. 32nd International Conference on Nursing & Healthcare
      February 20-21, 2023 • Las Vegas, USA

      The dashboard of Google Analytics traffic overview of “32nd International Conference on Nursing & Healthcare” clearly reflects the interests of the global enthusiastic conference attendees like Presidents, CEO’s, Clinical Nursing, Nursing scientists and researchers in Nursing, Delegates and industrial executives from nursing and healthcare industries, Nursing Education from around the globe who are searching to attend and present/exhibit their research/organization findings on highly acknowledged international conferences like ours with the web traffic a total of about 2,25,455 visits. The total page views were close to 4,43,995 where our reports are analysed half yearly.

    5. Gene Therapy for Muscular Disorders
      February 21-23, 2023 • Boston MA

      Efficiently Target & Transduce Muscle Cells to Reduce Toxicity Risk, Increase Efficacy, & Administer High Dose Systemic Genetic Therapies Safely. The past twelve months have seen an unprecedented level of excitement, investment, and progression within the gene therapy for muscular disorders field. As the industry endeavours to move gene therapy treatment through the preclinical and clinical pipeline, in context of reducing toxicity and increasing efficacy, attending the 3rd Annual Gene Therapy for Muscular Disorders Summit has never been so crucial. This year’s summit will return to Boston to reunite 100+ leading experts in biotech, pharma and academia to continue to develop strategies to deliver safer and more effective gene therapies to muscle cells.
    6. 2nd GPCRs – Targeted Drug Discovery Summit 2023
      February 21-23, 2023 • Boston, MA

      We are delighted and extremely glad to announce our Webinar entitled “International Webinar on Global Healthcare” will be held on May 29-30, 2023. The program will grab on both international and regional speakers’ who are experts in Healthcare and Medicine knowledge. Topics would be focused on common and updated scientific knowledge with the theme of “To explore the advanced and emerging techniques in healthcare”.
    7. 2nd Next Generation Kinase Inhibitors Summit
      February 22-23, 2023 • Boston, MA

      Increase the Specificity and Overcome Resistance of the Best-In-Class Kinase Inhibitor Products to Deliver Safe & Durable Clinical ResponsesWith strong effectiveness profiles and 20 years of FDA approval, kinase inhibitors have revolutionized oncology treatment. The success of current kinase inhibitor classes is nevertheless constrained by rising resistance and security concerns.The 2nd Next Generation Kinase Inhibitors Summit is the only industry-focused conference devoted to using novel kinase biology in drug development and innovating current programs to produce the next generation of kinase inhibitor drugs that can demonstrate effective and long-lasting clinical responses in oncology and other fields.
    8. 2nd International Conference on Gynecology & Obstetrics
      February 23-24, 2023 • Las Vegas, USA

      The Organizing Committee of the “2nd International Conference on Gynecology & Obstetrics” invites you to participate in the congress which will be held from February 22-23, 2023 which includes Prompt Keynote presentations, Oral, Poster Presentations and Exhibitions. The conference aims to foster and conduct collaborative interdisciplinary research in state-of-the-art methodologies and cutting edge technologies in Gynecology and Obstetrics through its invited presentation, submitted oral and poster abstracts the conference program focuses on theme “Current Research and Innovative Approaches towards Improving Women Reproductive Health”.
    9. Pain Management for the Non-Pain Specialist
      February 23-25, 2023 • Scottsdale, AZ US

      This course targets pain medicine across multiple of disciplines to address the national and international movement toward improved pain control. The course includes spine care review, pharmacologic management with opioid and non-opioid strategies, updates on common chronic pain conditions, and many other related clinical topics.
    10. Mayo Clinic Wound Symposium: The Edges of Wound Care 2023
      March 01-03, 2023 • Rochester, MN US

      This three-day course is designed to provide the latest diagnostic and treatment strategies for comprehensive wound management. The program is multidisciplinary with faculty representing various wound-related fields. Multiple educational formats are used, including didactic sessions, hands-on demonstrations, and case presentations that offer comprehensive wound-management strategies (from basics to high-level). The course meets the continuing education needs of a range of wound care providers, from novices to experts.
    11. PRESENT Treasure Hunt Conference
      March 04-05, 2023 • Hotel Indigo, Los Angeles, California

      PRESENT Treasure Hunt Conference is a state-of-the-art interactive CME-accredited medical conference held in Los Angeles, CA. Conference Chairmen are Drs Harold Schoenhaus, Robert Lee, and Gabriel Halperin. For the past 37 years, the PRESENT Treasure Hunt Conference has been a practice management-focused podiatry conference held by the Los Angeles County Podiatric Medical Association (LACPMA) for their 600 practicing podiatrists. This important conference in 2019 aligned with PRESENT to add exciting cutting edge CME and state-of-the-art rotating interactive workshops, without losing the place for podiatrists to go and learn practice management. This provided a more complete educational experience to all attendees at the PRESENT Treasure Hunt Conference. The education is provided by some of our nation’s top key opinion leaders from leading teaching institutions around the country including past presidents of LACPMA, APMA, and ACFAS. The education focuses on evidence-based and best practices for utilizing the latest surgical procedures, advanced wound care technologies, vascular interventions, as well as dermatology of the lower limb, biomechanics, biologic therapies, off-loading, compression therapy techniques, X-ray, fluoroscopy, and practice management including billing, coding, and health care policy.
    12. Echo Imaging in Colorado Including Multimodality Imaging: Ski Telluride
      March 06-09, 2023 • The Peaks Resort & Spa, Telluride, CO

      This program will provide a comprehensive review of state-of-the-art 2-D, 3-D, M-Mode, Doppler and transesophageal echocardiography with a strong emphasis on newer and more rapidly changing areas. The topics to be covered include diastology, ischemic heart disease, valvular heart disease, application of TEE in clinical practice, for cardiomyopathy and planning, preforming and following interventions. The role of echo relative to the newer imaging modalities will be discussed. There are also afternoon workshops on valvular heart disease, hemodynamics, diastology, cardiomyopathy, and 3-D echo with a focus on integrating various imaging modalities to provide the highest quality of patient care. The course is designed for the clinician and sonographer who are actively involved in adult echocardiography and wish to gain additional practical experience in these specific areas. Daily reading sessions will provide the opportunity to interpret case studies and to compare and discuss diagnoses with the faculty. An integrated format combining theory and practice will be utilized. In the morning sessions, a traditional lecture series will present state-of-the-art information on selected topics. Application of the techniques to clinical practice will be emphasized.
    13. Mayo Clinic Psychiatry Clinical Updates 2023
      March 07-10, 2023 • Fairmont Orchid – Hawaii

      Mayo Clinic Psychiatry’s flagship course, Psychiatry Clinical Updates 2023, is aimed at providing clinically relevant updates for the management of psychiatric problems across the lifespan. Topics include updates and clinical pearls on mood and psychotic disorders, suicide, addiction, anxiety, perinatal psychiatry and eating disorders, as well as evidence-based psychotherapy and emerging pharmacotherapies. In addition, special topics relevant to current situations are presented.
    14. Targeted Intracellular Delivery Summit
      March 08-09, 2023 • Boston, MA

      It has long been understood that the ability to deliver therapeutic cargos to cytosolic sites of action in target tissue could unlock access to previously undruggable targets, whilst enabling the development of safer and efficacious drugs. Now, advances in nanomedicine technology, the LNP-enabled mRNA vaccine and modern medicine’s shift towards a more personalized model are fuelling excitement amongst drug developers as they position their pipelines towards utilizing novel delivery systems which effectively engage previously elusive intracellular targets. With mounting investments, industry collaborations and interest in leveraging next-generation nano vehicles, from LNP’s, liposomes, EV’s, polymeric nanoparticles (& beyond!), new avenues have been opened for optimizing the therapeutic index of novel pipelines, from antisense oligonucleotides, siRNA, mRNA & DNA delivery to peptide protein drugs.
    15. Healthcare Simulation Conference 2023: Elements, Essentials and Excellence in Healthcare Simulation
      March 09-10, 2023 • Hilton Rochester Mayo Clinic Area

      This in-person conference is designed to provide an opportunity for simulation educators and enthusiasts from clinical and academic settings to connect with colleagues from various professions and roles to share, learn, and grow in areas of simulation-based education, research, innovation, and technology. Grounded in evidence-based best practices, this conference is a platform for simulation novices to experts to gain and disseminate knowledge and skills from a basic overview to new directions in healthcare simulation. Registration includes an optional evening tour of the Mayo Clinic Simulation Center and other simulation facilities.
    16. 27th ESCRS Winter Meeting
      March 10-12, 2023 • Vilamoura, Portugal

      We are pleased to announce that the 27th ESCRS Winter Meeting will take place at the Tivoli Marina, Vilamoura Algarve in Portugal – from Friday 10 to Sunday 12 March 2023. After having to transition this year’s Winter Meeting to virtual, we are excited to be able to welcome the ESCRS community back to the Tivoli Marina, Vilamoura Algarve in Portugal for the 2023 ESCRS Winter Meeting as was initially planned for 2022. It is our great pleasure to bring the 2023 Winter Meeting to you in collaboration with the Sociedade Portuguesa Oftalmologia (SPO) and the Portuguese Groups of Cataract and Refractive Surgery, Ocular Surface, Cornea and Contactology (CIRP). Following the tradition of the ESCRS, the Winter Meeting takes place in a special setting, allowing a unique combination of attending a high-level programme whilst making most of the warm welcome of the host destination, Portugal.
    17. 13th World ADC London 2023
      March 13-16, 2023 • ExCeL London

      With the recent approvals of ImmunoGen’s ELAHERE, Astrazeneca and Daiichi Sankyo’s DESTINY-Breast04, supporting Enhertu’s use in HER2-low breast cancer as a new therapeutically targetable category, the ADC space has continued to make major waves throughout 2022, a joy to see for oncology patients around the world. With high hopes set on Byondis for the next approval, you simply can’t miss out on this highly anticipated event. Exploring all aspects of ADC development from discovery to late-stage manufacturing, this is your one-stop shop for antibody-drug conjugate content.
    18. Fierce BD&L Summit for Life Sciences 2023
      March 14-15, 2023 • San Francisco, CA

      The Fierce Business Development and Licensing (BD&L) Summit for Life Sciences brings together key deal-makers and serves as an open forum for cross-functional business development, due diligence, finance, and legal teams to share valuable insights and actionable strategies on successfully sourcing and evaluating new opportunities, conducting due diligence, and structuring licensing agreements and M&A deals.
    19. 7th International Congresses on Controversies in Rheumatology and Autoimmunity (CORA 2023)
      March 16-18, 2023 • Turin, Italy

      New autoimmune syndromes are being discovered and described rapidly by leading scientists and these findings raise further questions related to the clinical diagnosis, management, as well as the pathogenesis of rheumatic and autoimmune disorders. CORA 2023 will feature major and short debate sessions, scientific lectures, abstract presentations, sponsored blocks, as well as many other exciting new session types! CORA 2023 is where difficult clinical cases will be discussed by top experts.
    20. Heart Failure Management for NP, PA, and Primary Care Providers
      March 16-18, 2023 • In-Person or Livestream | Disney’s Yacht & Beach Club, Lake Buena Vista, FL

      This course delivers a comprehensive review of the diagnosis and management of heart failure across its multiple stages. Heart failure is a prevalent and costly disease causing debilitating symptoms and excess mortality. While cardiac subspecialists provide essential testing and treatment at various stages of heart failure care, the majority of patient management is handled by primary care providers. A clinical format will highlight the practice dilemmas and key management strategies essential to enhance the attendees’ confidence in caring for these challenging patients. To reinforce the knowledge gained from the course and ensure lasting value to each attendee’s practice, Mayo Clinic provides access to all course presentations with voice-over recordings after the completion of the course.
    21. 37th Annual New Treatments in Chronic Liver Disease CME Conference
      March 18-19, 2023 • San Diego, California

      This conference will review the latest medications and therapies in liver treatment and transplantation. The results of trials and real-world data using oral drugs to treat chronic viral hepatitis B and C, non-alcoholic fatty liver diseases, primary biliary cirrhosis, primary sclerosing cholangitis, hepatocellular carcinoma and complications of end-stage liver disease including thrombocytopenia will be reviewed in detail. New Treatments in Chronic Liver Disease is a comprehensive yet concise program for updating physicians on these and other commonly encountered problems in the treatment of liver diseases.
    22. 13th International Conference on Psychiatry, Psychology & Brain Studies
      March 20-21, 2023 • Singapore City, Singapore

      The EuroSciCon meeting on the Psychiatry 2023 spotlight on developments and the conceivable fate of Psychiatry from March 20-21, 2023 in Singapore City, Singapore. The subject of the back and forth movement year’s party is “Recent Research Achievements in Psychiatry” which will give an overall stage to discuss present and future difficulties in different sort of mental and cerebrum explore the issue, Psychiatry bearing, proceeding with getting ready and limit meeting. World-driving thriving authorities, clinicians, instructors, and specialists will demonstrate front line and sensible clinical methods in the context of completely perceived affirmation and will indicate new and make the examination.
    23. 3rd International Conference on Food and Packaging Technology
      March 20-21, 2023 • San Francisco, USA

      Euroscicon takes pleasure in inviting the scientific community across the globe to attend the 3rd International Conference on Food and Packaging Technology during March 20-21, 2023 San Francisco, USA. with a motto to Advancing the biotechniques and scientific research into Food Packaging and Technology Food Technology 2023 aims to discover advances in health practice opportunities and challenges for the Food technology, management, and education in relation to health disparities as well as a breadth of other topics. For abstract submission, please visit: Food technology 2023 Conference will encourage the Young Researcher’s Forum, scientists, and researchers in their early stage of career graph to widely discuss their outcomes so as to enrich and develop their idea. The ‘Best Poster Award’ is meant to encourage students in taking an active part in the International Science platform to sharpen their skills and knowledgebase.
    24. Next Generation Genetic Vaccines Conference
      March 20-21, 2023 • London, United Kingdom

      SAE Media Group is proud to announce the Inaugural Next Generation Genetic Vaccines Conference taking place on the 20th – 21st March 2023.
      As part of SAE Media Group’s leading series of conferences, this year’s event will bring together expertise from individuals across the vaccine community. The two-day conference will offer a series of presentations, through which you will gain insight into the latest developments in advancing the pre-clinical and clinical translation of genetic vaccine development. With COVID-19 leading to the rapid acceleration of the vaccines industry and a specific focus on genetic vaccines, the conference will consider the latest technologies and platforms such as mRNA being developed and utilised within the space. Integration of novel vaccine development into pre-clinical studies all the way to clinical will be covered, with case studies on applications in oncology and infectious diseases. This year’s conference will also touch on how artificial intelligence can be used to transform vaccine research and development.
    25. 8th International Conference on Diabetes and Obesity
      March 22-23, 2023 • London, UK

      Euroscicon is proud to host the “8th International Conference on Diabetes and Obesity” happening during March 22-23, 2022 in London, UK. The conference is themed around “Evolutions in the field of Diabetes & Obesity Procedures and Treatment” with the aim to assemble a large audience of trade, healthcare, research, and medical practitioners to coach and produce a few fruitful discussions on the confined topics. This can be an excellent event to network, learn and have interaction with professionals within the field of polygenic disease and fat. Benefits of Participation: Diabetes 2023 is open for Oral papers, Poster shows and scientific panel discussions across the highlighted sessions within the web site and proposals on alternative topics that don’t seem to be listed also are welcome provided, they meet the objectives of the conference. We are focusing to inspire, discuss, and work along to bring out an answer for numerous issues related to polygenic disorder and medicine.
    26. 6th International Congress on Pharmaceutics & Drug Delivery
      March 23-24, 2023 • Rome, Italy

      Conference Series LLC Ltd is going to host “6th International Congress on Pharmaceutics & Drug Delivery” which is going to be held during , March 23-24,2023 in Rome, Italy with the theme “Creating breakthrough medicines to improve the quality of life”. We are welcoming all the Speakers and Delegates from every corner of the World to join us at Pharmaceutics & Drug Delivery 2023. Asia Pharmaceutics 2023 is going to offer scientific talks by Keynote Speakers, Oral talks, Symposiums, Poster Presentation, Exhibitions and many more. Asia Pharmaceutics 2023 will offer an International platform where Scholars and experts belonging to the Pharmaceutical background and working in that field can showcase their scientific work, research based on the following topics such as Pharmaceutics, Pharmacy, Drug delivery, Drug targeting and many more. Industries related to Pharmaceutical and Drug manufactures are all invited to showcase their advanced product so that their products can get exposure. Our main agenda is to share the latest information on Pharmaceutics for the betterment of mankind.
    27. The 14th Annual Congress on Controversies in Ophthalmology (COPHy)
      March 24-25, 2023 • Epic Sana Lisboa

      Join us at 14th Annual Congress on Controversies in Ophthalmology (COPHy) which will be held on March 24-25, 2023 in the beautiful city of Lisbon, Portugal. COPHy 2023 will continue to focus on the debates concerning controversial issues in ophthalmology, the core of the congress. Leading world experts will present two opposed approaches to controversial issues. Each topic presented will be followed by a live discussion of ophthalmologists experienced in the area being discussed.
    28. 30th Annual Nicotine Dependence Center Conference: Tobacco Treatment and Digital Care
      March 27-28, 2023 • Phoenix, AZ US

      The 30th Annual Nicotine Dependence Center Conference reviews current best practice models for providing compassionate, patient-centered care and highlights digital and virtual care options. In addition, the conference presentations provide the latest information on the changing landscape of tobacco and nicotine use and product regulations.
    29. Simulation Workshop SW23
      March 27-29, 2023 • National Oceanographic Centre, Southampton

      The OR Society’s Simulation Workshop brings together our community of experts working in the field of modelling and simulation. Hosted at the National Oceanography Centre in Southampton, SW23 will provide an opportunity for practitioners and academics to exchange ideas on the current and future state-of-the-art in modelling and simulation.
    30. Scripps 2023 Primary Care in Paradise CME Conference
      March 27-30, 2023 • Maui, Hawaii

      Scripps Health’s Primary Care in Paradise conference was designed for primary care physicians and the interdisciplinary care team and will present content from their unique perspective. This important CME conference will educate and promote improved patient outcomes in a broad range of therapeutic areas commonly encountered in the busy primary care practice. In addition to an overview of the history and current science of a variety of specialty areas, content will be presented in a very practical, patient-focused manner relevant to the specific primary care setting and challenges.
    31. 3rd Gene Therapy Comparability Summit
      Boston, MA • March 28-30, 2023

      In the context of ever-important gene therapy scale-up to achieve commercial goals and mounting regulatory scrutiny, the 3rd Annual Gene Therapy Comparability Summit is the only event focused on comparability of gene therapy. Join 150+ Quality Assurance, CMC, Regulatory, Analytical and Process Development experts from pharma and biotechs to provide you with hands-on, practical insights into exactly what it takes to ensure you can maintain safety, quality, consistency, and efficacy while adapting manufacturing processes, methods and platforms, to adhere to regulatory demands and avoid costly delays to clinical programs.
    32. Scaling Digital Health Solutions 2023
      March 28-30, 2023 • Boston, MA

      Digital health solutions hold the potential to revolutionize patient treatments – and with the shifting landscape of healthcare characterized by critical shortages of medical staff, growing prevalence of chronic diseases, and move towards at-home care, the demand has never been higher. But even the most innovative products can’t sell themselves. The 2023 Scaling Digital Health Solutions Summit provides you with the actionable insights you need to take your product from sketch to launch, and into the hands of the patients who need them. Uniting DTx, saMD, and AI/ML companies, alongside pharma, investors, and regulators, next March join your peers to hear the latest success stories on securing coding, coverage, and payment, integrating into clinical workflows, and continuously improving products post-launch. This meeting will provide an unrivalled opportunity to solve your current commercialization challenges, by improving your ability to get reimbursement, navigate the regulatory landscape, and establish mutually beneficial partnerships.
    33. 3rd Targeted Protein Degradation Europe Summit
      March 28-30, 2023 • London, UK

      The Targeted Protein Degradation Europe Summit returns to London for its 3rd year, providing a central touchpoint to obtain critical updates and learnings from key European biopharma leaders, and delve into vital early discovery and preclinical challenges on the road to robust clinical pipelines. As a more technical and mechanistic centred forum, this summit is built with European TPD professionals and global technical TPD experts in mind, as these two tracks, three-day forum will navigate through:
      Enhance the Selectivity, Bioavailability and PKPD to Ensure Safety, Efficacy and Potency. Progress Computational Modelling of TPD to Improve Structural Predictions and Understand Selectivity. Optimising Degrader Design via Enhanced Assay Selection and Development. Emerging Degradation Strategies from AUTACs and LYTAC’s. Emerging Targets and Indications for Protein Degradation Beyond Oncology
    34. Lab Asset and Facility Management in Pharma Summit Europe
      March 28-30, 2023 • London, UK

      Not only has the pandemic fuelled life science investment, but it has also made us realise the importance of seamless R and D operations and lab facility requirements. Over the last 2 years we have seen huge investments into expanding R and D infrastructure within Europe; including a new £500m new biocluster in Canary Wharf in London, Velo3D opening a new European technical centre in Germany and the LabConnect announcement of increasing their footprint in Europe. Amidst these investments and expansion plans in the LS sector, Lab Operations, R and D Asset and Facility leaders in biopharma are playing an increasingly vital role to ensure internal capabilities and external supplier management are fit-for-purpose to support their scientific teams and R and D pipeline progression.
    35. TCR-based Therapies for Solid Tumors Summit
      April 03-05, 2023 • Boston, MA

      The first TCR-based therapy approval in the US and Europe at the start of this year sparked a rush of excitement, investment and collaborations. As further developers move into the clinic and some near commercialization, it’s time for this community to unite to address the critical bottlenecks faced in development, from discovery to approval, to guarantee smooth sailing through the clinic. The 4th TCR-based Therapies for Solid Tumors Summit is returning to Boston as the must-attend forum for TCR experts to come together to share industry updates and next generation engineered approaches to boost therapy safety and efficacy.
    36. 10x Medical Device Conference
      April 11-13, 2023 • Wyndham San Diego Bayside

      10x Medical Device Conference is the cross-functional event where the medical device industry unites to grow your skills, network, and profit. It’s designed to foster strong professional relationships among medical device players eager to learn smarter ways to do things with industry-leading resources. For what level? This medical device event is geared equally for senior and junior level professionals in the medical device industry. If you’re senior, you’ll return with ideas the team can use. If junior, you’ll return with specific lessons, materials, and action items to do your job better.
    37. High Performance Resuscitation Teams – 2023
      April 13-15, 2023 • Minneapolis, MN US

      This course will review critical concepts and operationalize implementation practices for High Performance Resuscitation Teams. Attendees will explore how team members acquire, process and make information actionable, including strategies for effective communication, collaboration and cooperation. Experts in the field will focus on situations of high risk and high consequences, as well as, constructive communication in intense and highly emotional scenarios.
    38. Heart to Heart: Advances in Cardiovascular Critical Care and Resuscitation
      April 13-15, 2023 • In-Person or Livestream | Fairmont Scottsdale Princess, Scottsdale, AZ

      This symposium will highlight the management and new technology utilized in the critical care unit to care for patients admitted. Expert faculty will provide up-to-date education on multifaceted care for patients presenting with myocardial infarction, heart failure, cardiac rhythm disorders, and shock along with appropriate imaging, monitoring, and medical management. Special attention will be given to limiting complications in the cardiovascular care units for best-practice principles. The program will have didactic lectures integrated with challenging case discussions to highlight this rapidly growing field of medicine and a novel break-out session addressing optimal team dynamics in resuscitation.
    39. 20th International Conference on Allergy and Clinical Immunology
      April 17-18, 2023 • Chicago, USA

      Greetings from Immunology 2023!! This is an official Invitation to join 20thInternational Conference on Allergy and Clinical Immunology 2023 during April 17-18, 2023, in Chicago, USA. The scientific program is designed with Oral presentations, posters along with delegate participations. If you are not able to travel, you can still participate virtually for our conference, we are not letting scientific events go down because of pandemic situations. If you wish to get global recognition for your research abstracts and research profile at scientific community. you wish to publish abstracts indexed in Global Scientific Databases by our leading international journals
    40. 6th Neoantigen Summit Europe
      April 24-26, 2023 • Leonardo Royal Hotel Amsterdam

      From screening technologies directing identification, prediction, and validation of neoantigens; to translating personalised medicine to the clinic, the 6th Annual Neoantigen Summit Europe returns to Amsterdam, as the only summit in Europe dedicated to advancing exclusive tumour antigen discovery and personalised therapeutic development within the world of immunotherapy. Devoted to the successful discovery, translation, and development of individualised neoantigen vaccines and cell immunotherapies, join 150+ experts at the forum, as they navigate validation of neoantigen targets and review methodologies/technologies to support with translating neoantigen-based studies effectively to the clinic.Join is in 2023 for the latest preclinical updates, and evaluate the hottest clinical data from leading biotechs, such as Nouscom, Gritstone, and BioNTech, CurVac.
    41. 5th Neuroimmunology Drug Development
      April 25-27, 2023 • Boston, MA

      Returning for its 5th year, the Neuroimmunology Drug Development Summit is excited to bring you pioneering insights from a range of brand-new speakers across the hottest biopharma in neuroimmunology to showcase revolutionizing breakthroughs in neuroinflammatory targeting. In 2023, you will enhance your understanding of underlying glial biology and neuroinflammatory pathways, address how to improve the development and translatability of neuroinflammatory biomarkers, and decipher the most effective in vitro and in vivo models to recapitulate all hallmarks of neuroglia. Join 100+ neuroimmunology and neuroinflammation industry experts across numerous neurological indications to define the next steps for accelerating the translation of neuroimmunology therapeutics into the clinic.
    42. ICRS Focus Meeting Allografts and Synthetics on the Frontstage
      April 27-29, 2023 • Nice, France

      Cartilage treatment has evolved over the latter years, and diagnostics, imaging and staging have increasingly been involved. Cartilage healing has become more documented as techniques have become more precise and case-sensitive. As the knee is an “organ” other issues like menisci and alignment will be part of this highly focused meeting supported by all partners. It is an opportunity for you to join those short days if you want to upgrade and update your knowledge for the better treatment of our patients. In addition, the programme focuses on the relationship between menisci and cartilage in the load-bearing joint bringing long-term results in meniscal allograft transplantation. This ICRS Focus meeting will also discuss the latest on bone and ligament allografts and alternatives.
    43. 11th International DIP Symposium on Diabetes, Hypertension, Metabolic Syndrome and Pregnancy
      May 04-06, 2022 • Thessaloniki, Greece

      Join us at the 11th International DIP Symposium on Diabetes, Hypertension, Metabolic Syndrome and Pregnancy: Innovative Approaches in Maternal Offspring Health which will be held on May 4-6, 2023 in the beautiful city of Thessaloniki, Greece DIP is considered a leading symposium in the field of Maternal and Fetal medicine, presenting data and management protocols to ensure the optimal outcome of pregnancies complicated by diabetes, hypertension and metabolic syndrome.
    44. WPA Thematic Congress 2023
      May 05-07, 2023 • Intercontinental, Abu Dhabi, UAE

      The theme of the conference, “Innovations in the treatment and psychosocial rehabilitation”, is very important and relevant to current practice of psychiatry especially during and post Covid 19 pandemic. I am pleased that the meeting also plans to cover other important topics of interest including entire field of mental health with a strong focus on the issues of practice of psychiatry in low and middle income and developing countries. Links of WPA scientific sections with WPA membership emphasize the important of establishing contacts by promoting exchange of professional expertise around the globe. The presence of several eminent speakers from all over the region along with a number of academic and clinical psychiatrists from other countries highlights the importance of this academic activity.
    45. 8th International Conference on Primary Healthcare & Management
      May 08-09, 2023 • Zurich, Switzerland

      The organizing Committee for Primary Healthcare 2022 takes immense pleasure to welcome attendees from around the globe to attend the “8th International Conference on Primary Healthcare and Management” Scheduled during May 08-09, 2023 in Zurich, Switzerland which includes inciting keynote, oral, poster presentation & exhibitions.
    46. 41st Annual Meeting of the European Society for Paediatric Infectious Diseases
      May 08-12, 2023 • Lisbon & Online

      We will bring together world-renowned researchers and clinicians for a very exciting multi-faceted programme covering areas that include clinical issues, epidemiology, public health, microbiology, immunology, host-pathogen interactions, genomics, and their interfaces, highlighting more recent progress and also where advances have been more challenging, ESPID is the world\’s premier paediatric infectious diseases meeting for professionals who want to stay up to date, apply state-of-the art science to clinical care, present their research, reinforce existing and develop new collaborations. There will be ample opportunities for networking in Lisbon, a fascinating city that combines a great historical heritage with modernity and vibrant culture. We are absolutely delighted to be able to welcome you to ESPID 2023!
    47. Bio-IT World
      May 16-18, 2023 • Hynes Convention Center, Boston MA & Virtual

      The Bio-IT World Conference & Expo is the world’s premier event showcasing the technologies and analytic approaches that solve problems, accelerate science, and drive the future of precision medicine. For over 20 years, the Event has united a community of leading life sciences, pharmaceutical, clinical, healthcare, informatics, and technology experts in the fields of biomedical research, drug discovery & development, and healthcare from around the world. During May 16-18, 2023, the Bio-IT World Conference & Expo will return to the Hynes Convention Center in Boston (with a live virtual stream as well) and once again host the conversations that connect people, ideas, and opportunities that are advancing research and innovation. Join your peers for updates from inspiring keynotes, more than 190 presentations, and 3 days of interactive discussion. Let’s continue holding each other accountable for pushing the Bio-IT community forward!
    48. Mayo Clinic “Teach the Teachers” Elbow Course 2023 – Trauma
      May 18-20, 2023 • Rochester, MN US

      Mayo Clinic’s 25th Edition “Teach the Teachers” Advanced Elbow Surgical Skills Course Forge the Future: Trauma is an advanced level course designed for orthopedic surgeons with a special interest in upper extremity trauma, elbow surgery and trauma surgery. The course provides technical skills orientation, with the didactic portions limited to the necessary introductions and theoretical knowledge required for the technical components. Live surgical broadcasts used during lecture sessions demonstrate surgical techniques pertaining to this year’s topic of elbow trauma as well as other areas of elbow orthopedics.
    49. Musculoskeletal: Ultrasound Hands-on Diagnostics and Guided Interventional Skills
      May 20-21, 2023 • Livestream

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Innovations, Insights from a Seasoned Venture Capitalist

20 min reading time

Innovations, Insights from a Seasoned Venture Capitalist

Presented by Maurizio Vecchione
at the 10x Medical Device Conference – San Diego, 2022

Reading Time: 20 minutes

Maurizio Vecchione: It’s actually part of the Gates Foundation, and it uses a standard methodology to create stochastic statistical models that would predict the impact of a device that does not yet exist or an intervention that does not yet exist on a particular country against either seasonal or other factors relating to the disease.

This happens to be Madagascar. It’s simulating the presence of malaria and the impact on malaria on a new intervention relating to a next generation of mosquito bed net, and it’s a very simplistic, it’s a very simple problem, but this allows somebody designing an intervention or designing a product or designing to essentially simulate, using these kind of impact metrics, what is the likely impact that they’ll have? And at the Gates Foundation, these type of techniques are used to actually decide what to invest in, and so I’m telling you that because this is becoming now mainstream.

These kinds of approaches are becoming mainstream, not only in public policy but in in investment circles. So I run a venture capital fund as an example, and we’re using the same exact techniques to pick the problems we’re gonna be backing.

10x returns to San Diego, with Maurizio as keynote! Join us April 11, 2023.

Note: The following was autotranscribed by and got probably 80+ percent correct without edits. Interpret accordingly.

As I sort of come to perhaps a 30-year point in my career, in medical devices, both on the research side, and on the development side. And increasingly on the investment side, and the policy side, I thought it would be good to share with you kind of a mega picture of some reflections on what I think is just around the corner from us, predicated by a series of innovations that are really very likely to change completely in the face of medical devices that may be not in today. Now, medical devices is a very broad term. So not everything that I’m going to be talking to you today is relevant for everyone in the audience, I’m sure, an enormous data. But I thought it will be good for you to sort of think and reflect a little bit about some of the trends that I’m seeing convergence rapidly. And I think maybe ushering in what I would describe as a new golden age of devices. You know, most of you are probably very intimately familiar with the impact of software, and technology, and increasingly machine learning. I hesitate calling it artificial intelligence. Because it really is not intelligence. It’s not artificial. Machine learning. Statistical intelligence, develops correlations, not necessarily causation. But we’re about to see the next evolution of that which will go into cognitive intelligence and reasoning systems, which are likely to really change the way machines and humans interface. So, I thought I’ll title this conversation disruptive medical devices.

And I’m not entirely sure whether this conversation is going to be completely realistic, or completely coherent. So please stop me and ask questions, feel free to disagree. I thought about throw up a series of trends that I’m increasingly seeing as dominating the discourse in terms of the evolution of healthcare and healthcare delivery, as well as some of the frontiers that are encompassed in this in the medical device space. There’s a lot of talk about precision medicine, people define it differently. I’m not sure there’ll be totally believe the role of precision medicine in the future of healthcare outcomes. But especially in areas like cancer, increasingly, positive outcomes coming only when you apply precision medicine, of course, the basic tenet of precision medicine is you’re going to use genetic profiling to essentially customize treatments and other procedures. And that inherently means there are devices involved, and athletes involved in performing their precision medicine calculation, but this is going to become much more than that. And, and devices will take a role in precision medicine is not only to profile and been patients, but it’s going to become the way drugs are actually developed. And I’m going to come back to that the subject of treating sickness versus treating wellness. Preventing disease before it becomes disease is also an increasing factor. If any of you track my old boss Bill Gates, you may have watched his TED Talk and 2015. And in 2015, Bill predicted down to the economic impact, that type of virus predicted COVID pandemic. And he was off by maybe a year in terms of when it all happened now, how did it predict it? He predicted it, because when you look at these issues of prevention, you can pretty much see what is going to happen to the etymology of disease. And you can make some very important public health conclusions from it.

The other sort of mega trend that I want to call your attention is this move to clinical care. Increasingly, your doctor is this, and the relationship of patients to healthcare is completely changed. I was at the breakfast table, I was sharing a piece of data, I happened to be on a panel that is advising the British Prime Minister on the future of the National Health Service in the UK. And as part of that, there was a recent study that was conducted that basically showed that the push towards specialized care is increasingly counterproductive on the outcomes of the patients. And a particular aspect of this study showed us 77 0% of all patients in British hospitals will be actually better off being at home and be treated in primary care. So, you know, in different pieces, statistics, I live in Los Angeles, and the west side of Los Angeles, which is a relatively affluent, maybe 3 billion people section on the city has more MRI machines than the entire combined Western European total of MRI machines. Does that mean that the average West Los Angelenos is healthier than the average Western European? No, it just means we have a much more expensive healthcare system. This idea of immediately moving patients out of primary care, out of wellness care, out of preventive care into acute and specialist care is really becoming an issue both from a cost and personal perspective, and from a outcome’s perspective. And then the big one, you know, the word diagnostic, has been around for a long time. But really, we haven’t had the devices that are therapeutic. With some exceptions, you could argue with cardiovascular care, and a few other things, devices are performing therapeutic function. But the idea that the device could replace a drug, for some kind of therapeutic aspect is pretty new. And I will show you in a minute the trends in the science and technology that are ushering this new era of devices becoming therapeutic. These are some of the topics I want to talk about. I skipped a few, but you see them there. For me to into that, I like to come back to why are we in the medical devices business. And, and this is something that takes me back to a 10 plus years of investing Bill Gates as money for impact in general healthcare, delivery devices, spaces, you know, increasingly, and we’re just living through a crisis in population had through the COVID pandemic. Increasingly, the impact of the medical technologies that we’re all involved with has the potential to transform the world.

As a matter of fact, there are some technologies that are incubating today that could completely radically transform the way we think about disease on such a scale, that it would be planetary scale. We’re also increasingly seeing a convergence between the health of the planet and the health of the people on the planet. And if you happen to have attended the last climate conference, the conference in Glasgow, you may have been surprised to see a major crisis by the World Health Organization and a 500-page report that is actually looking at the impact on healthcare from climate change. And of course, a lot of people will say, okay, you know, because the climate is getting warmer, and we’re going to have mosquitoes in places that we didn’t have mosquitoes. So maybe we’ll have malaria in places that didn’t have malaria. By the way, there’s malaria in Florida. At the moment. You might have heat strokes in places that don’t have heat strokes and so on. But it’s actually much more dynamic than that. If you think about it, the planet is a Petri dish. And we’ve found out the heat and so there is accelerated genomic and evolutionary pressures on pathogens and disease. And if you think that it’s an accident that we have a pandemic now, or if you think that it’s an accident that over the last 15 years, we had 22 pandemic potential bugs emerge when we didn’t have any for the prior 100 plus years. Well, let me tell you, it’s not an accident. So, this idea of One Health, the idea of zoonosis, and diseases that escaping from animals to humans, of course, I’m talking about effective diseases. But this has effects on a bit of theology across the disease space. I wanted you to think a little bit about the impacts of what we’re doing. And for a different reason, in addition to sort of being humanitarians and high mining, during the 10 years of investing almost $30 billion in medical devices for Bill, I discovered the correlation. And the correlation is from a business perspective, the biggest was the impact of our products and devices, the biggest source of performance, financial performance, and the outcome of the company so we build. Some of our biggest unicorns that come out of that effort were companies that achieve the highest human potential human impact. And so, I would argue to you as you think about these megatrends, as you think about the next thing, as you think about the evolution of your products, think about their impact, because high impact might just be a great business strategy to ultimately achieve global scale. And if you don’t think about the impact, then you have to think about impact in the quantitative way. You know, I probably have 50 business plans on my desk for new devices, new products, and every one of them started by saying, we are solving X problem, and it’s the most important problem to solve in medical history. Well, I’m not trying to say your disease is more important than that disease.

But you need a methodology to try to really assess the true impact of some of these products. And so my thesis around the strategy for high impact innovation centers on the concept of modality. And if you’re not in public health, you might not know what that means. But this was a metric of impact that was actually developed by Gates. It was subsequently adopted by the World Health Organization, and it’s in use to measure the impact of disease pretty much across the world, in Delhi stands for disability adjusted life years. And, you know, when you think about a disease, and when you think about a human, we have a sudden life expectancy, in that life expectancy is affected by the times when we are sick. And you could essentially calculate the number of years that we lose from sickness. And that’s the measure of the value. And I can tell you a recipe for how to ensure that your product is disruptive, and scale embedded, scalable, and that is to maximize the number of calories that you save, at the lowest possible cost per gallon. When you achieve that you almost by definition, have products that will transform the world. And so, the reason why I’m telling you all that is because you can incorporate these types of metrics into creating pictures like this, this is the entire global burden of disease. For the entire world. The size of each box represents the area, which box represents the impact that the disease has expressed in down, upon the left blue box is IHD, that’s ischemia and heart disease. And not surprisingly, you can see that, that’s one of your largest areas of impact. If you could eliminate it, maybe combining it with stroke. If you could eliminate it, you’d be close to eliminating the border of our normal bone disease expressed the tally. Some of the highest impact companies that I’ve seen execute successfully map the products into these title pictures and make decisions of where to put investments and where to put market strategies based on these actual and projected impact areas. Now of course, it’s easy to say eliminate ischemia heart disease is a high impact thing. But then the real question is, what do you need to do to make a difference in that particular box. Yes, what is the question?

Rob Packard: I have a little trouble reading the graph, but I think it says this is to 2017. Is that correct?

Maurizio Vecchione: Yes, my plot is a little bit dated.

Rob Packard: The diabetes portion is has exploded recently. So, we really need to look at this real time as well. Right?

Maurizio Vecchione: You’re correct. And it’s for that reason that I created in about eight years ago, I created a Public Benefit Research Institute called the Institute of Health Metrics and Evaluation. It’s run by Dr. Personal Rafe previously from Harvard. Now at the University of Washington, if you go to, or you will do a search around the global burden of disease, you’ll actually see an open database, yes, the world’s largest repository of tally data. And you can see an open database that you can actually use to make these kinds of assessments and not only you will use it, but every government uses it. And every multilateral uses it. Anytime you see a piece of data that says the coordinates of the prevalence of certain diseases X or Y, it comes from the ihme dataset. And they are constantly updated and it is real time. And in parallel, you can see off to the right there, those sort of intensity of the colors, they represent the speed at which a particular condition is increasing or decreasing, you’re right. It’s a very dynamic process, but the data is all open.

Joe Hage: I’ll just say, I’m just going to say that. I know you’re all fascinated with him. And I know he has more slides than we had a lot of time for. Go over. And I encourage you to ask him questions, because yes, he is fascinating.

Pablo Prado: I am Pablo Prado from Livivos. I was just asking, what’s the color code in your…

Maurizio Vecchione: Yeah, the column called the Blue is non-communicable disease, the red is the effective disease. And the green is other condition like car accidents. And again, the intensity is the growth rate. The darker ones are growing, the lighter ones are shrinking. Okay, and but again, this is just a snapshot, okay, you will get very different pictures, if you ask the question about this burden of disease for the United States, or for the Western United States, or for, you know, Africa. And you will see massive shifts, which eternal think about what that means, it means that different parts of the world, different populations are dealing with a different burden of disease that we are at, if you’re going to be designing devices, or designing for a new pack, you have to keep all that in mind. Okay, now, I’m going to give you a glimpse of how far you can take this. This is out of another institute that we created a Gates, it’s actually part of the Gates Foundation. And it uses the stallion methodology to create stochastic statistical models that will predict the impact of a device that does not yet exist. Or an intervention that does not yet exist on a particular country against either seasonal, or other factors relating to the disease, this happens to be Madagascar, it’s simulating the presence of malaria and the impact on malaria or a new intervention relating to the next generation, mosquito bed net. And it’s a very simplistic, it’s very simple problem. But this allows somebody designing an intervention or designing a product or design to essentially simulate using these kinds of impact metrics, what is the likely impact that they’ll have? And at the Gates Foundation, these types of techniques are used to actually decide what to invest in. And so I’m telling you that because this is becoming now mainstream, these kinds of approaches are becoming mainstream, not only in public policy, but in investment circles. So, I run a venture capital fund is an example and we’re using the same exact techniques to pick the province we’re going to be backing. And again, with a desire to maximize the impact. Okay…

Joe Hage: I’m just close enough. If you go back to, I was, one more place. I was intrigued because I was watching the day count. Yeah. And it went red where it was most intense to bluer and I was assuming that was the positive impact of your intervention, but then we’re ready again for blue again.

Maurizio Vecchione: Yeah, you’re actually see because it happens to be talking about malaria, there is a seasonal factor due to the fact that malaria is spread by mosquitoes and as the wet season, Madagascar, there is a climate and weather component to the measurement of this impact. And that’s why you need very sophisticated simulation. It’s not just the presence of the intervention, but it’s what’s happening to the disease all in the dynamic fashion.

David Giles: Got a question, Dave Giles from Battelle. Going back to the terminal boxes, a lot of those are lifestyle related. So, does this mean that we are misallocating resources as a society by focusing on medical devices as or pharmaceuticals as a therapy, versus treating the lifestyle?

Maurizio Vecchione: Perhaps, that’s why I want you to see this, because when you start looking at these kinds of pictures, then you can ask some fundamental question whether you are on the product development side, and you need to think about the impact of the usability or the positioning of your product. You know, and it goes back to the comment I said, at the beginning, when people start talking about prevention, you know, you might have a much higher impact on the world preventing some of this disease with lifestyle. By the way, that doesn’t mean devices are not important. One of the most successful areas of implementation of devices is behavioral therapies that are actually looking at those kinds of implementation. The reason why I want you to think in terms of impact, first, I want you I’m advocating is because I think it will get you to develop the strategies that are the most impactful and most effective at the end. And I think, by the way, that concept affects any area that you’re involved, whether it’s regulatory, whether it’s product development, whether it’s research, or whether its business.

Rob Packard: My name is Rob Packard, I think that’s exactly the right question to ask are we misallocating resources? Put it in the context of FDA submissions, which is what I specialize in. When we have clients with an innovative technology, they automatically think, Oh, this is a breakthrough device designation. In the requirements for a breakthrough device designation, they ask for is what life-threatening disease are you treating with this device? And where’s your clinical data for this? But one way to twist his show, it really has more impact on society would be? What is your daily impact?

Maurizio Vecchione: Absolutely. And again, when you start thinking about at the level of quantitation of valleys is you know, you have to sort of realize that I’ll give you an example. During cancer, of course, it has a big dally impact. Okay, but is anyone most likely to achieve that? By itself? Probably not, it needs to live inside a continuum that will in aggregate, contribute only maybe one specific type of cancer or one stage of the cancer, etc. The devil is in the detail. And when you actually start translating the value of innovation that I saw, you need to really ask the question, what are the gaps that science and technology hadn’t filled? That causes this to be such a big box? Okay, and maybe that the answer is behavioral, or lifestyle, okay, or a combination of factors. And then by the time you get to the FDA, and by the way, I’m a consultant with a number of the FDA groups right now on this very topic, because they need to be equipped to be able to assess the impact and it gets very specific. That’s why we went through the trouble of Gates to actually build sophisticated models that could give us a prediction on the specific intervention, the specific product in a specific geography in the context of whatever disease, you’re tracking. Now, this is over the top sophisticated and against we had 200 people developing state of the art, you know, statistical and predictive models to do this kind of things. But you can do a quick and dirty version of this, that I actually have in all of the companies that I’ve invested in, we tried to drive a methodology inside the management team thinking. As we now sort of take these impacts, and we started thinking about where and what can we do with devices to try to drive these impacts, you know, I like to think in terms of cost, and ease of use as sort of a parameter space.

And what has happened with the introduction of technology, as well as all of the revolutions around omics and other sort of biological sciences, life sciences, really the emergence of system biology, is you’ll be able to take things that were historically high cost and historically difficult to use require physicians or physician radiation to utilize and they’re slowly moving to the point of care, which means that moving up the axis of ease of use and now abandoned dramatically come down in costs. And so, the yellow box there, which really is the thing you need to move care outside of the hospital setting or the high-end setting, and move it into the customer, the customers hand, the home. And the decentralized setting is one of the key frontiers we’re seeing in devices. And I’m going to just leave you with a couple of examples that I consider case studies on how that evolution is occurring. This is a premium product not yet on the market, but it is already in front of the FDA. It happens to be a company that I incubated in my current research effort. And it’s intended to address a number of those big boxes that you saw before. Specifically, it’s focusing on ischemia, heart disease, and stroke. And what you’re seeing is a wearable device that is, probably if the clinical data supports, it will shape up to be the best stroke detector. And it’s entirely available as a point of care devices automated. This is a device that can look inside your head, and actually determine the very precisely the blood flow patterns. And can tell you if you have a stroke, where you have a stroke in approximately 60 seconds. And it’s intended to dramatically affect the way stroke care is provided. Because today, when an ambulance comes, if they suspect that you have a stroke, it’s based on visual interpretation of certain symptoms and a scale.

And chances are, the ambulance is going to take you to the nearest hospital, and the nearest hospital may not be equipped to do procedures that could come back to me, which is the thing that is going to save your life if you have a large vessel occlusion stroke. And if you get to that thrombectomy, after about two hours on the answers to stroke, your outcomes are very, very poor. Which is why stroke is such a big box in that valley better than ever before. On the other hand, if he gets you to a hospital that can do that dramatically within that two-hour magic window, when you are going to be almost completely recovered. And so, this is a device that ultimately will be in every ambulance. It has a cost because it’s slipstream behind consumer electronics, product lines, that is sub $500. And it’s an automatic way of deciding what kind of stroke you have, and where do you need to be taken. This is an example but here’s where some of the magics that’s happening. Well, we can see inside your brain with a device like this, and it’s using a new technology called harmonic excitation.

But it turns out, we can also not only see the neurons, but we can poke the neurons. And so, this is a device that utilized in a slightly different way becomes therapeutic. And some of the indications that are currently in front of the FDA are neuropsychiatric disease, therapeutic for Alzheimer, and therapeutic for breakers. And it’s because a device that can essentially reach inside your brain and touch those neurons and create harmonic excitations has the ability to do cell lysis on cancer and has the ability to do neuro stimulation on neuropsychiatric disease. And it’s all a wearable piece of product. Now, there are techniques to do these kinds of things. Today, they involve roomful of equipment, and hundreds of 1000s of dollars per see. And patients having to do extenders six times a week, visiting hospitals, that can now all come to a sub-treatment, automatic treatment at home. This is an example of what I mean when you start thinking in terms of the problem areas. And you start thinking about the convergence of these technologies, what can be achieved in some of the technologies that are making these kind of things possible, listed right on here, the idea that you can incorporate the advances in omics with advances in tissue engineering and cell biology with personalized constructs, including the ability to create personalized disease models, and so called organs on a chip, all combined into personalized biomaterials in turn enable the construction of these devices that are the sort of highly convergent capabilities. And to give you a separate case study, I’ll tell you a little bit about the work that Terasaki institute is doing on organs on a chip.

Joe Hage: I’d like to ask about that. Who is that? Is that a company you’ve founded?

Maurizio Vecchione: No, the Terasaki Institute is a non-profit, loosely affiliated with UCLA. It runs a research center that we’re pioneers on Dr. Porter Sack a pioneer in transplantation. And they are now developing a lot of personal medicine, technology as a research institution.

Joe Hage: How did you become involved with that? How did that transition from what you were doing to this? So how did you become involved with it?

Maurizio Vecchione: Absolutely, Seattle, my real home. I was in LA and the Terasaki Institute is a fantastic place that is doing really leading-edge research. It’s a good place for me to bring some of my academic research and I focus on helping them develop a research program that is ultimately highly translatable and can spawn company. NICU Terasaki is a research center at some incubator, and accelerator.

Joe Hage: I’ll say that the end to celebrate, I made the executive decision on cutting it in coffee break, so we can hear and speak some more, right.

Maurizio Vecchione: And I’m almost done, you may have heard of assays that mimic organs and an ordinary behavior. But increasingly, you can create assets that mimic human disease, such as cancer and you can integrate those into other in vitro models that can mimic metabolic functions and other functions in the competence of optimizing drug treatments or discovering drugs. And because this is a human, the translation from model to reality is dramatically better. And this is what I’m showing you here is the future of drug discovery, in the translation for most animal models to humans, is less than 7% for drugs, which is why it costs so much to development, new drug and many fail, in later stage, you can kind of skip all that, and go directly into these sorts of personalized models.

And, you know, you can put these things inside microfluidic circuits that can mimic function, but more importantly, produce data in real time. Think of this as a organoids bio reactor that are creating living human organs and are integrating them with living human disease. And you can study those interactions in real time using these kinds of systems. And to give you a sense of where the tissue engineering has gone, this is artificial heart tissue, you can see it naturally starts pulsing and you can look at cardio toxicity. And finally, individual assays using this kind of technology. And, and we can do this from liver, and look at metabolic functions. More importantly, they do this for the immune system, and studying things like cancer immunology directly onto this onshore construct. As you can imagine, when you combine this with big data, when you combine this with genomics and personalized medicine, we are now at the point that places I can be honest, if you’re a cancer patient, you’ll be able to go inside MD Anderson, they will take a biopsy of your cancer, that will create living organoids, that they’ll put aside machines that can generate essentially hundreds of 1000s of replica. And they will test every chemotherapy drugs across for your specialized treatment. And they will do that in a matter of days.

And the outcome changes when you do that is the difference between a one size fits all treatment to a highly responsive, specific treatment. And that’s what we’ve looking at this for the future, new drugs, discovery. These are devices that are becoming tools for drug discovery, as well as they’re becoming therapeutics by themselves. And this is just part of a recently published study, where we actually predicted using this vitro construct, we predicted some of the most spectacular cardiovascular drug failures. And it couldn’t be done in vitro at the very beginning. Because we could see in the living organoids the cardiac toxicity that they weren’t so awesome here, what I hoped of these years.

Joe Hage: In more than two years. I’m wondering, you inspired, and people want to get that guy’s contact information. I know. How do you choose which of that many projects to work on first? How do you make a choice when your time is limited?

Maurizio Vecchione: I use that impact metric. So yes, some permutation of that concept, basically all you could spend your life chasing any one problem. And I’m telling you if you chase the high impact problem and if you look, find the problem in front. That’s the other issue, especially research, I see all the time researchers that have made a breakthrough. And then they ask the question, we’re going to do this. And some of our most successful programs can when we submit the problem, and we define the problem, and we take scientists from an interdisciplinary area and put them in a room saying, here’s the problem we can solve. Okay, if you solve that, we have a business, we have a funding, we have other things to really allow for this. And that idea of doing problem first development, you’ll be surprised how few people actually do.

Jan Gates: A quick question, sounds a little bit strange, I’m Jan Gates from PackWise Consulting. But 23 years ago, there were doctors trying to do what you were talking about with the cell technology in individualized chemotherapy and everything. And they were banned from medical practice. How did you get pass that with the FDA and the doctors and stuff.

Maurizio Vecchione: It’s the predictive value, you know, you can do subculture and look at drug susceptibility of the individual cells. And that is predictive to the limited extent, drug companies do that all day long. Physicians may not be necessarily doing that, but within drug discovery industry, that’s one of the key techniques. I think the understanding of biology, Cell Biology system biology, when you’re looking at something like that cardiac tissue is showing you another discipline that is also highly disrupted called tissues engineering, because the functioning of the cardiac tissues, not just subsets. When you go back to the example of the neuro stimulation technology, the functioning of a technology is not just based on sub-neurons, it’s based on the entire coexistence of those multiple cell types in a living tissue. And that’s why the technology has evolved to really replicate the complex living organoids that exercise and physiology that is associated with those. It’s only at that point that you also gaining predictive value. And in fact, that these technologies are now becoming common place will allow us to simulate it like there are machines that literally have this in the box.

Joe Hage: Please, thank my fascinating friend Maurizio Vecchione.